Serum Apelin-12 Concentration in Saudi Obese Middle-Aged Men

Apelin-12 is one of the most potent forms of apelin, an adipocytokine that might contribute to the decrease in body weight. The aim of this project was to compare the level of serum apelin-12 in obese and nonobese middle-aged men and to assess the relationship of serum apelin-12 concentration with anthropometric parameters and lipid profile. In this cross-sectional study, 150 obese men (body mass index (BMI) ≥ 30kg/m) of age range between 35-56 years were selected. For the purpose of comparison, 140 non-obese age-matched men (BMI ≤ 25kg/m) were chosen as a control group. Anthropometric parameters were measured and peripheral blood samples were obtained for biochemical assays. Serum apelin levels were determined by enzyme-linked immunosorbent assay (ELISA). The data showed that serum apelin-12 levels were not significantly (P=0.48) different between the obese and the non-obese men. The serum apelin-12 levels did not correlate with the anthropometric parameters and the lipid profile in the two groups. The finding of this research suggests that serum apelin-12 concentration is not involved in the pathological mechanism of obesity in middle-aged men. [Rowyda Nawwaf Al-Harithy. Serum Apelin-12 Concentration in Saudi Obese Middle-Aged Men. Life Sci J 2014;11(10):1113-1117]. (ISSN:1097-8135). http://www.lifesciencesite.com. 167